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Columbia is a city in the U.S. state of Missouri. It is the county seat of Boone County and home to the University of Missouri. Founded in 1821, it is the principal city of the three-county Columbia metropolitan area. It is Missouri's fourth most populous with an estimated 128,555 residents in 2022. As a Midwestern college town, Columbia maintains high-quality health care facilities, cultural opportunities, and a low cost of living. The tripartite establishment of Stephens College (1833), the University of Missouri (1839), and Columbia College (1851), which surround the city's Downtown to the east, south, and north, has made Columbia a center of learning. At its center is 8th Street (also known as the Avenue of the Columns), which connects Francis Quadrangle and Jesse Hall to the Boone County Courthouse and the City Hall. Originally an agricultural town, education is now Columbia's primary economic concern, with secondary interests in the healthcare, insurance, and technology sectors; it has never been a manufacturing center. Companies like Shelter Insurance, Carfax, Veterans United Home Loans, and Slackers CDs and Games, were founded in the city. Cultural institutions include the State Historical Society of Missouri, the Museum of Art and Archaeology, and the annual True/False Film Festival and the Roots N Blues Festival. The Missouri Tigers, the state's only college athletic program which sponsors FBS football, play football at Faurot Field and basketball at Mizzou Arena as members of the rigorous Southeastern Conference. The city rests upon the forested hills and rolling prairies of Mid-Missouri, near the Missouri River valley, where the Ozark Mountains begin to transform into plains and savanna. Limestone forms bluffs and glades while rain dissolves the bedrock, creating caves and springs which water the Hinkson, Roche Perche, and Bonne Femme creeks. Surrounding the city, Rock Bridge Memorial State Park, Mark Twain National Forest, and Big Muddy National Fish and Wildlife Refuge form a greenbelt preserving sensitive and rare environments. The Columbia Agriculture Park is home to the Columbia Farmers Market. The first humans who entered the area at least 12,000 years ago were nomadic hunters. Later, woodland tribes lived in villages along waterways and built mounds in high places. The Osage and Missouria nations were expelled by the exploration of French traders and the rapid settlement of American pioneers. The latter arrived by the Boone's Lick Road and hailed from the culture of the Upland South, especially Virginia, Kentucky, and Tennessee. From 1812, the Boonslick area played a pivotal role in Missouri's early history and the nation's westward expansion. German, Irish, and other European immigrants soon joined. The modern populace is unusually diverse, over 8% foreign-born. White and black people are the largest ethnicities, and people of Asian descent are the third-largest group. Columbia has been known as the "Athens of Missouri" for its classic beauty and educational emphasis, but is more commonly called "CoMo".

Missouri ( miz-OOR-ee) is a landlocked state in the Midwestern region of the United States. Ranking 21st in land area, it borders Iowa to the north, Illinois, Kentucky and Tennessee to the east, Arkansas to the south and Oklahoma, Kansas, and Nebraska to the west. In the south are the Ozarks, a forested highland, providing timber, minerals, and recreation. The Missouri River, after which the state is named, flows through the center and into the Mississippi River, which makes up the eastern border. With over six million residents, it is the 18th-most populous state of the country. The largest urban areas are St. Louis, Kansas City, Springfield, and Columbia; the capital is Jefferson City. Humans have inhabited present-day Missouri for at least 12,000 years. The Mississippian culture, which emerged at least in the ninth century, built cities and mounds before declining in the 14th century. When European explorers arrived in the 17th century, they encountered the Osage and Missouria nations. The French incorporated the territory into Louisiana, founding Ste. Genevieve in 1735 and St. Louis in 1764. After a brief period of Spanish rule, the United States acquired Missouri as part of the Louisiana Purchase in 1803. Americans from the Upland South rushed into the new Missouri Territory; Missouri played a central role in the westward expansion of the United States. Missouri was admitted as a slave state as part of the Missouri Compromise of 1820. As a border state, Missouri's role in the American Civil War was complex, and it was subject to rival governments, raids, and guerilla warfare. After the war, both Greater St. Louis and the Kansas City metropolitan area became centers of industrialization and business. Today the state is divided into 114 counties and the independent city of St. Louis. Missouri has been called the "Mother of the West", the "Cave State", and the "Show Me State". Its culture blends elements of the Midwestern and Southern United States. It is the birthplace of the musical genres ragtime, Kansas City jazz and St. Louis blues. The well-known Kansas City-style barbecue, and the lesser-known St. Louis-style barbecue, can be found across the state and beyond. Missouri is a major center of beer brewing and has some of the most permissive alcohol laws in the U.S. It is home to Anheuser-Busch, the world's largest beer producer, and produces an eponymous wine produced in the Missouri Rhineland and Ozarks. Outside the state's major cities, popular tourist destinations include the Lake of the Ozarks, Table Rock Lake and Branson. Some of the largest companies based in the state include Cerner, Express Scripts, Monsanto, Emerson Electric, Edward Jones, H&R Block, Wells Fargo Advisors, Centene Corporation, and O'Reilly Auto Parts. Well-known universities in Missouri include the University of Missouri, Saint Louis University, and Washington University in St. Louis.